Pharmacogenomics: Tailoring Drug Therapy to Genetics

Abstract

Pharmacogenomics studies how genetic variations affect drug response, enabling personalized medicine. For example, variations in the CYP2C19 gene influence responses to drugs like clopidogrel, used in cardiovascular treatment. Testing for genetic markers can optimize drug selection and dosing, reducing adverse effects.

Applications include psychiatry, where genetic profiles guide antidepressant selection, and oncology for targeted therapies. Challenges include limited access to testing and ethical concerns over genetic data. Advances in sequencing technologies are expanding its clinical adoption.

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